Gene

IRC5

Species
Saccharomyces cerevisiae
Symbol
IRC5
Name
Increased Recombination Centers
Synonyms
  • YFR038W
Biotype
protein coding gene
Automated Description
Predicted to enable several functions, including ATP hydrolysis activity; chromatin binding activity; and nucleosome array spacer activity. Involved in mitotic recombination. Acts upstream of or within error-free translesion synthesis. Located in nucleus. Human ortholog(s) of this gene implicated in immunodeficiency-centromeric instability-facial anomalies syndrome 4. Orthologous to human HELLS (helicase, lymphoid specific).
SGD Description
Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci; SWAT-GFP and mCherry fusion proteins localize to the nucleus
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10799:SF923
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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229.5k230.0k230.5k231.0k231.5k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions