Enables chromatin binding activity and protein kinase binding activity. Involved in several processes, including G2/M transition of mitotic cell cycle; chromosome organization; and replication-born double-strand break repair via sister chromatid exchange. Located in condensed nuclear chromosome and mitochondrion. Part of mitotic cohesin complex. Used to study Cornelia de Lange syndrome and Roberts syndrome. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome; Cornelia de Lange syndrome 4; endometrial cancer; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to several human genes including RAD21L1 (RAD21 cohesin complex component like 1).
SGD Description
Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis; subject to proteolytic cleavage by separase Esp1p, resulting in dissociation of cohesin from chromatin and the separation of sister chromatids at the mitotic metaphase-to-anaphase transition; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase