Gene

MCD1

Species
Saccharomyces cerevisiae
Symbol
MCD1
Name
Mitotic Chromosome Determinant
Synonyms
  • PDS3
  • RHC21
Biotype
protein coding gene
Automated Description
Enables chromatin binding activity and protein kinase binding activity. Involved in several processes, including G2/M transition of mitotic cell cycle; chromosome organization; and replication-born double-strand break repair via sister chromatid exchange. Located in condensed nuclear chromosome and mitochondrion. Part of mitotic cohesin complex. Used to study Cornelia de Lange syndrome and Roberts syndrome. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome; Cornelia de Lange syndrome 4; endometrial cancer; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to several human genes including RAD21L1 (RAD21 cohesin complex component like 1).
SGD Description
Essential alpha-kleisin subunit of the cohesin complex; required for sister chromatid cohesion in mitosis; subject to proteolytic cleavage by separase Esp1p, resulting in dissociation of cohesin from chromatin and the separation of sister chromatids at the mitotic metaphase-to-anaphase transition; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12585:SF29
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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444.8k445.0k445.2k445.4k445.6k445.8k446.0k446.2k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions