Enables phospholipid binding activity and sterol binding activity. Involved in intracellular sterol transport. Located in fungal-type vacuole lumen. Used to study Niemann-Pick disease and Niemann-Pick disease type C2.
SGD Description
Sterol transport protein, functional homolog of human NPC2 Niemann-Pick disease type C2 protein; together with Ncr1p mediates integration of ergosterol into vacuolar membrane; functions as general “lipid solubilizer”, binds variety of amphiphilic lipid ligands; targeted to vacuole via Vps10p-dependent endosomal vacuolar protein sorting pathway; yeast NPC2 can complement mutations in human NPC2