Gene

HEM25

Species
Saccharomyces cerevisiae
Symbol
HEM25
Name
HEMe synthesis by SLC25 family member
Synonyms
  • YDL119C
Biotype
protein coding gene
Automated Description
Enables glycine transmembrane transporter activity. Involved in glycine import into mitochondrion and heme biosynthetic process. Located in mitochondrion. Used to study sideroblastic anemia. Human ortholog(s) of this gene implicated in autosomal recessive pyridoxine-refractory sideroblastic anemia 2. Orthologous to human SLC25A38 (solute carrier family 25 member 38).
SGD Description
Mitochondrial glycine transporter; required for the transport of glycine into mitochondria for initiation of heme biosynthesis, with YMC1 acting as a secondary transporter; homolog of human SLC25A38, a mitochondrial glycine transporter associated with nonsyndromic autosomal recessive congenital sideroblastic anemia; human SLC25A38 can complement the heme deficiency associated with the null mutant; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46181:SF3
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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246.7k246.8k246.9k247.0k247.1k247.2k247.3k247.4k247.5k247.6k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions