Version: 8.0.0Date: Tue Jan 28 2025
Gene
CDC13
- Species
- Saccharomyces cerevisiae
- Symbol
- CDC13
- Name
- Cell Division Cycle
- Synonyms
- EST4
- YDL220C
- Biotype
- protein coding gene
- Automated Description
- Enables single-stranded telomeric DNA binding activity; telomerase inhibitor activity; and translation elongation factor binding activity. Involved in regulation of telomere maintenance via telomerase; ribonucleoprotein complex localization; and telomere maintenance. Acts upstream of or within negative regulation of DNA duplex unwinding. Located in chromosome, telomeric region. Part of CST complex.
- SGD Description
- Single stranded DNA-binding protein found at TG1-3 telomere G-tails; key roles regulating telomerase, telomere end protection, and telomere replication; can dynamically intermolecularly exchange between telomeric single-stranded DNA molecules; essential function is telomere capping; forms homodimer via N-terminus; disruption of dimerization leads to short telomeres; autophagy and proteasome are involved in Cdc13p degradation; differentially phosphorylated through cell cycle
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR14513:SF0
Stringency:
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Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
Phenotype Term | Annotation details | References |
|---|---|---|
| abnormal budding index | ||
| abnormal cell cycle progression in G2 phase | ||
| abnormal cellular morphology | ||
| abnormal chromosome/plasmid maintenance | ||
| abnormal protein/peptide distribution | ||
| absent sporulation | ||
| arrested cell cycle progression | ||
| decreased chromosome/plasmid maintenance | ||
| decreased heat sensitivity | ||
| decreased lifespan |
Disease Associations
Cases where the expected disease association was NOT found
| all annotations | all disease by infectious agent | bacterial infectious disease | fungal infectious disease | parasitic infectious disease | viral infectious disease | all disease of anatomical entity | cardiovascular system disease | central nervous system disease | endocrine system disease | gastrointestinal system disease | hematopoietic system disease | immune system disease | integumentary system disease | musculoskeletal system disease | peripheral nervous system disease | reproductive system disease | respiratory system disease | sensory system disease | thoracic disease | urinary system disease | all disease of cellular proliferation | benign neoplasm | cancer | pre-malignant neoplasm | all genetic disease | chromosomal disease | monogenic disease | polygenic disease | all other disease | disease of mental health | disease of metabolism | physical disorder | syndrome | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CDC13 (Sce) |
Cell color indicative of annotation volume
No data available
Alleles and Variants
- Genome location
- ChrIV:62244...65018 - (2.77 kb)
- Assembly version
- R64-5-1
- Viewer Help
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
|---|---|---|---|---|---|---|---|
| cdc13-273 | allele | Yes | |||||
| cdc13-S249A | allele | Yes | |||||
| cdc13-Y626A | allele | ||||||
| cdc13-E867R | allele | Yes | |||||
| cdc13-F237A | allele | ||||||
| cdc13-S611L | allele | Yes | |||||
| cdc13-F684A | allele | Yes | |||||
| cdc13-7 | allele | Yes | |||||
| cdc13-231 | allele | Yes | |||||
| cdc13-243 | allele | Yes | |||||
Sequence Feature Viewer
- Genome location
- ChrIV:62244...65018 - (2.77 kb)
- Assembly version
- R64-5-1
- Viewer Help
Expression
- Primary Sources
- Other Sources
| all annotations | all cellular components | extracellular region | plasma membrane | synapse | cell junction | cell projection | cytoplasmic vesicle | endosome | vacuole | golgi apparatus | endoplasmic reticulum | cytosol | mitochondrion | nucleus | chromosome | cytoskeleton | protein-containing complex | other locations | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CDC13 (Sce) |
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.