Gene

KGD2

Species
Saccharomyces cerevisiae
Symbol
KGD2
Name
alpha-KetoGlutarate Dehydrogenase
Synonyms
  • YDR148C
Biotype
protein coding gene
Automated Description
Enables dihydrolipoyllysine-residue succinyltransferase activity. Involved in 2-oxoglutarate metabolic process and cellular respiration. Located in mitochondrial nucleoid. Part of oxoglutarate dehydrogenase complex. Human ortholog(s) of this gene implicated in Alzheimer's disease and paraganglioma. Orthologous to human DLST (dihydrolipoamide S-succinyltransferase).
SGD Description
Dihydrolipoyl transsuccinylase; component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43416:SF5
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
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      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R64-5-1
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            753.8k754.0k754.2k754.4k754.6k754.8k755.0k

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            KGD2 molecule type
            Interactor gene
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              Genetic Interactions

              KGD2 role
              KGD2 genetic perturbation
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