Enables DNA binding activity and chromatin binding activity. Contributes to histone deacetylase activity. Involved in negative regulation of transcription by RNA polymerase II and regulatory ncRNA-mediated gene silencing. Located in cytosol and nucleus. Part of HDA1 complex.
SGD Description
Subunit of HDA1 histone deacetylase complex; tetrameric trichostatin A-sensitive class II histone deacetylase complex contains Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance; Hda2p relocalizes to cytosol in response to hypoxia; other members of the HDA1 histone deacetylase complex, which regulates aging through trehalose metabolism, are Hda1p and Hda3p