Enables protein-macromolecule adaptor activity. Involved in rescue of stalled ribosome and ribosome-associated ubiquitin-dependent protein catabolic process. Located in cytoplasm. Part of RQC complex. Orthologous to human TCF25 (transcription factor 25).
SGD Description
Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Rkr1p-Rqc2p-Cdc48p-Npl4p-Ufd1p) is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Rkr1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC