Species

Saccharomyces cerevisiae

Symbol

SNF1

Name

Sucrose NonFermenting

Synonyms

CAT1
CCR1

Biotype

protein coding gene

Automated Description

Enables AMP-activated protein kinase activity and guanyl-nucleotide exchange factor activity. Involved in several processes, including invasive growth in response to glucose limitation; positive regulation of filamentous growth of a population of unicellular organisms; and regulation of carbohydrate biosynthetic process. Located in cellular bud neck septin ring; nuclear envelope lumen; and vacuolar membrane. Part of nucleotide-activated protein kinase complex. Human ortholog(s) of this gene implicated in Huntington's disease; breast cancer; colon cancer; and type 2 diabetes mellitus. Orthologous to human PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1) and PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2).

SGD Description

AMP-activated S/T protein kinase (AMPK); complexes with Snf4p and a Sip1p/Sip2p/Gal83p family member; required for glucose-shortage induced respiratory gene expression, heat shock, sporulation, and peroxisome biogenesis; regulates filamentous growth; acts as a non-canonical GEF activating Arf3p during invasive growth; role in mitotic spindle alignment in non-limiting glucose; phosphorylates Kcs1p; target of SUMO-dependent, Ub-mediated destruction; polyhistidine tract acts as a pH sensing module

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR24343:SF466

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Show functions with at least one experimental evidence

Pathways

No data available

Phenotypes

Primary Sources

SGD

Other Sources

None

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Disease Associations

Include negative annotationsCases where the expected disease association was NOT found

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Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

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Sequence Feature Viewer

Genome location

ChrIV:1412373...1414274 + (1.90 kb)

Assembly version

R64-5-1

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Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

SNF1 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
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Genetic Interactions

SNF1 role	SNF1 genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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