Gene

MMS2

Species
Saccharomyces cerevisiae
Symbol
MMS2
Name
Methyl MethaneSulfonate sensitivity
Synonyms
  • YGL087C
Biotype
protein coding gene
Automated Description
Contributes to ubiquitin-protein transferase activity. Involved in several processes, including free ubiquitin chain polymerization; postreplication repair; and protein targeting to vacuolar membrane. Located in fungal-type vacuole membrane and nucleus. Part of ubiquitin conjugating enzyme complex. Orthologous to human PEDS1-UBE2V1 (PEDS1-UBE2V1 readthrough); UBE2V1 (ubiquitin conjugating enzyme E2 V1); and UBE2V2 (ubiquitin conjugating enzyme E2 V2).
SGD Description
Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24068:SF143
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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346.45k346.50k346.55k346.60k346.65k346.70k346.75k346.80k346.85k346.90k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions