Contributes to ubiquitin-protein transferase activity. Involved in several processes, including free ubiquitin chain polymerization; postreplication repair; and protein targeting to vacuolar membrane. Located in fungal-type vacuole membrane and nucleus. Part of ubiquitin conjugating enzyme complex. Orthologous to human PEDS1-UBE2V1 (PEDS1-UBE2V1 readthrough); UBE2V1 (ubiquitin conjugating enzyme E2 V1); and UBE2V2 (ubiquitin conjugating enzyme E2 V2).
SGD Description
Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress