Version: 8.0.0
Date: Tue Jan 28 2025
COQ8
Saccharomyces cerevisiaeSGD:S000003087
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

COQ8

Species
Saccharomyces cerevisiae
Symbol
COQ8
Name
COenzyme Q
Synonyms
  • ABC1
  • YGL119W
Biotype
protein coding gene
Automated Description
Enables ATP hydrolysis activity; lipid binding activity; and protein kinase activity. Involved in ubiquinone-6 biosynthetic process. Located in mitochondrial matrix. Used to study coenzyme Q10 deficiency disease; nephrotic syndrome type 9; and primary coenzyme Q10 deficiency 4. Human ortholog(s) of this gene implicated in coenzyme Q10 deficiency disease; nephrotic syndrome type 9; and primary coenzyme Q10 deficiency 4. Orthologous to human COQ8A (coenzyme Q8A) and COQ8B (coenzyme Q8B).
SGD Description
ATPase required for ubiquinone biosynthesis and respiratory growth; maintains levels of CoQ biosynthetic proteins; binds to CoQ biosynthesis intermediates; UbiB protein kinase-like family member that lacks canonical protein kinase activity; similar to prokaryotic proteins involved in ubiquinone biosynthesis; human homolog ADCK3 complements a coq8 null, is associated with CoQ and respiratory-chain deficiencies, and is mutated in autosomal-recessive cerebellar ataxia type 2
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43851:SF3
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
    References
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R64-5-1
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            284.6k284.8k285.0k285.2k285.4k285.6k285.8k

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            COQ8 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              COQ8 role
              COQ8 genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
              Reference
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