Species

Saccharomyces cerevisiae

Symbol

SCS3

Name

Suppressor of Choline Sensitivity

Synonyms

FIT2B
YGL126W

Biotype

protein coding gene

Automated Description

Predicted to enable coenzyme A diphosphatase activity. Involved in phospholipid biosynthetic process. Acts upstream of or within phospholipid homeostasis. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Siddiqi syndrome. Orthologous to human FITM1 (fat storage inducing transmembrane protein 1) and FITM2 (fat storage inducing transmembrane protein 2).

SGD Description

Protein required for normal ER membrane biosynthesis in response to ER stress; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis; human homolog FIT2/FITM2, a fatty acyl-CoA diphosphatase, complements the yeast null mutant; disputed role in the synthesis of inositol phospholipids from inositol; required for inositol prototrophy

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR23129:SF0

Stringency:StringentModerateNo filter

Additional filters to further constrain the results:

Best Score OnlyBest Reverse Score Only

Count:Species:Methods:

Species	Gene symbol	Count	Best	Best reverse	Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiens	FITM2	4 of 9	Yes	Yes	☑ ☑☐☐☑☐☑☐☐
Homo sapiens	FITM1	4 of 9	Yes	Yes	☑ ☑☐☐☑☐☑☐☐
Mus musculus	Fitm1	4 of 9	Yes	Yes	☑ ☑☐☐☑☐☑☐☐
Mus musculus	Fitm2	4 of 9	Yes	Yes	☑ ☑☐☐☑☐☑☐☐
Rattus norvegicus	Fitm2	4 of 9	Yes	Yes	☑ ☑☐☐☑☐☑☐☐
Rattus norvegicus	Fitm1	4 of 9	Yes	Yes	☑ ☑☐☐☑☐☑☐☐
Xenopus tropicalis	fitm2	4 of 9	Yes	No	☑ ☑☐☐☑☐☑☐☐
Danio rerio	fitm1l	4 of 9	Yes	Yes	☑ ☑☐☐☑☐☑☐☐
Danio rerio	fitm2	4 of 9	Yes	Yes	☑ ☑☐☐☑☐☑☐☐
Drosophila melanogaster	Fitm	4 of 9	Yes	Yes	☑ ☑☐☐☑☐☑☐☐
Caenorhabditis elegans	fitm-2	4 of 9	Yes	No	☑ ☑☐☐☑☐☑☐☐

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources

SGD

Other Sources

None

Phenotype Term

Annotation details

References

abnormal endoplasmic reticulum morphology

View

PMID:32915949

abnormal lipid particle morphology

View

PMID:33033181

abnormal vacuolar morphology

View

PMID:23383298

auxotrophy

View

Name	Type	Experimental condition	References
scs3-H235A	allele	has condition: chemical: inositol	PMID:32915949
scs3-H350A	allele	has condition: chemical: inositol	PMID:32915949
scs3-Δ	allele	has condition: temperature: elevated temperature, 37 °Cchemical: inositol	PMID:19841481
scs3-Δ	allele	has condition: chemical: myo-inositol	PMID:22927826
scs3-Δ	allele	has condition: chemical: inositol	PMID:32915949

decreased competitive fitness

View

decreased resistance to chemicals

View

Name	Type	Experimental condition	References
scs3-Δ	allele	has condition: chemical: BAPTA	PMID:17314395
scs3-Δ	allele	has condition: chemical: quinine	PMID:21960436
scs3-Δ	allele	has condition: chemical: cerulenin	PMID:22927826
scs3-Δ	allele	has condition: chemical: paromomycin	PMID:22927826
scs3-Δ	allele	has condition: chemical: D-1,4-dithiothreitol	PMID:22927826
scs3-Δ	allele	has condition: chemical: CG-1521	PMID:24968945
scs3-Δ	allele	has condition: chemical: diethyl phthalate	PMID:35715465

haploinsufficient

View

PMID:22244311

increased competitive fitness

View

PMID:23103169

increased resistance to chemicals

View

PMID:22927826

viable

View

PMID:12140549

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Disease Associations

Must provide at least one subject

Cell color indicative of annotation volume

Species	Gene	Association	Disease Qualifier	Disease	Evidence	Source	Based On	References
No records match query. Try removing filters.

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Alleles and Variants

Genome location

ChrVII:270997...272139 + (1.14 kb)

Assembly version

R64-5-1

Viewer Help

Data currently unavailable; sequence viewer under construction

Allele/Variant Symbol	Allele Synonyms	Category	Variant
scs3Δ		allele		Yes
scs3-H235A		allele		Yes
scs3-Δ	scs3-delta	allele		Yes
scs3-1		allele
scs3-H350A		allele		Yes
NC_001139.9:g.271683A>G		variant	NC_001139.9:g.271683A>G SNP synonymous variant
NC_001139.9:g.271816C>T		variant	NC_001139.9:g.271816C>T SNP missense variant
NC_001139.9:g.271853G>A		variant	NC_001139.9:g.271853G>A SNP missense variant
NC_001139.9:g.271422T>C		variant	NC_001139.9:g.271422T>C SNP synonymous variant

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View detailed Alleles/Variants information

Download all Alleles/Variants for all genes of the species

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location

ChrVII:270997...272139 + (1.14 kb)

Assembly version

R64-5-1

Viewer Help

Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

Other Sources

Must provide at least one subject

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

213 interactor genes based on 309 annotations

SCS3 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
protein	ACT1	Saccharomyces cerevisiae	protein	protein complementation assay	biogrid:2885368	PMID:33033181
protein	ADH1	Saccharomyces cerevisiae	protein	protein complementation assay	biogrid:2885335	PMID:33033181
protein	ALG2	Saccharomyces cerevisiae	protein	protein complementation assay	biogrid:2885330	PMID:33033181
protein	ALG3	Saccharomyces cerevisiae	protein	protein complementation assay	biogrid:2885331	PMID:33033181
protein	ATG22	Saccharomyces cerevisiae	protein	protein complementation assay	biogrid:2885363	PMID:33033181
protein	AVT1	Saccharomyces cerevisiae	protein	protein complementation assay	biogrid:2885364	PMID:33033181
protein	BAP2	Saccharomyces cerevisiae	protein	protein complementation assay	biogrid:2885347	PMID:33033181
protein	BEM4	Saccharomyces cerevisiae	protein	two hybrid	biogrid:113287	PMID:10688190
protein	CAB3	Saccharomyces cerevisiae	protein	protein complementation assay	biogrid:2885336	PMID:33033181
RNA	CCR4	Saccharomyces cerevisiae	protein	affinity chromatography technology	biogrid:2351475	PMID:29158339

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Genetic Interactions

SCS3 role	Interactor gene	Interactor species	Interactor role	Interaction type	Phenotype or trait	Source	Reference
unspecified role	AAH1	Saccharomyces cerevisiae	unspecified role	negative genetic interaction (sensu BioGRID)	colony size	biogrid:380040	PMID:20093466
unspecified role	AGP1	Saccharomyces cerevisiae	unspecified role	negative genetic interaction (sensu BioGRID)	colony size	biogrid:2116213	PMID:27708008
unspecified role	AMD1	Saccharomyces cerevisiae	unspecified role	negative genetic interaction (sensu BioGRID)	colony size	biogrid:2116244	PMID:27708008
unspecified role	APL5	Saccharomyces cerevisiae	unspecified role	positive genetic interaction (sensu BioGRID)	colony size	biogrid:211066	PMID:16269340
unspecified role	APL5	Saccharomyces cerevisiae	unspecified role	positive genetic interaction (sensu BioGRID)	colony size	biogrid:206557	PMID:16269340
unspecified role	ARL1	Saccharomyces cerevisiae	unspecified role	positive genetic interaction (sensu BioGRID)	colony size	biogrid:211065	PMID:16269340
unspecified role	ARL1	Saccharomyces cerevisiae	unspecified role	positive genetic interaction (sensu BioGRID)	colony size	biogrid:322203	PMID:19269370
unspecified role	ARL1	Saccharomyces cerevisiae	unspecified role	positive genetic interaction (sensu BioGRID)	colony size	biogrid:206753	PMID:16269340
unspecified role	ARP1	Saccharomyces cerevisiae	unspecified role	negative genetic interaction (sensu BioGRID)	colony size	biogrid:2116229	PMID:27708008
unspecified role	ATP10	Saccharomyces cerevisiae	unspecified role	negative genetic interaction (sensu BioGRID)	colony size	biogrid:2116241	PMID:27708008

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