Gene

CHC1

Species
Saccharomyces cerevisiae
Symbol
CHC1
Name
Clathrin Heavy Chain
Synonyms
  • SWA5
  • YGL206C
Biotype
protein coding gene
Automated Description
Predicted to enable clathrin light chain binding activity. Involved in Golgi to endosome transport; cortical actin cytoskeleton organization; and endocytosis. Predicted to be located in several cellular components, including clathrin-coated pit; cytoplasmic vesicle membrane; and cytosol. Predicted to be part of clathrin complex. Predicted to be active in actin cortical patch. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 56. Orthologous to human CLTC (clathrin heavy chain) and CLTCL1 (clathrin heavy chain like 1).
SGD Description
Clathrin heavy chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; the clathrin triskelion is a trimeric molecule composed of three heavy chains that radiate from a vertex and three light chains which bind noncovalently near the vertex of the triskelion; the light chain (CLC1) is thought to regulate function
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10292:SF1
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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103.0k103.5k104.0k104.5k105.0k105.5k106.0k106.5k107.0k107.5k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions