Predicted to enable clathrin light chain binding activity. Involved in Golgi to endosome transport; cortical actin cytoskeleton organization; and endocytosis. Predicted to be located in several cellular components, including clathrin-coated pit; cytoplasmic vesicle membrane; and cytosol. Predicted to be part of clathrin complex. Predicted to be active in actin cortical patch. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 56. Orthologous to human CLTC (clathrin heavy chain) and CLTCL1 (clathrin heavy chain like 1).
SGD Description
Clathrin heavy chain; subunit of the major coat protein involved in intracellular protein transport and endocytosis; the clathrin triskelion is a trimeric molecule composed of three heavy chains that radiate from a vertex and three light chains which bind noncovalently near the vertex of the triskelion; the light chain (CLC1) is thought to regulate function