Enables phospholipase A2 activity. Involved in cardiolipin acyl-chain remodeling. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Chanarin-Dorfman syndrome; autosomal recessive congenital ichthyosis 1; and colon adenocarcinoma. Orthologous to several human genes including ABHD4 (abhydrolase domain containing 4, N-acyl phospholipase B).
SGD Description
Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58