Gene

CLD1

Species
Saccharomyces cerevisiae
Symbol
CLD1
Name
CardioLipin-specific Deacylase
Synonyms
  • YGR110W
Biotype
protein coding gene
Automated Description
Enables phospholipase A2 activity. Involved in cardiolipin acyl-chain remodeling. Located in mitochondrial inner membrane. Human ortholog(s) of this gene implicated in Chanarin-Dorfman syndrome; autosomal recessive congenital ichthyosis 1; and colon adenocarcinoma. Orthologous to several human genes including ABHD4 (abhydrolase domain containing 4, N-acyl phospholipase B).
SGD Description
Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR42886:SF29
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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713.8k714.0k714.2k714.4k714.6k714.8k715.0k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions