Predicted to contribute to first spliceosomal transesterification activity and second spliceosomal transesterification activity. Involved in mRNA splicing, via spliceosome. Located in cytosol and nucleus. Part of Prp19 complex and U2-type spliceosomal complex.
SGD Description
Member of the NineTeen Complex (NTC); NTC contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; relocalizes to the cytosol in response to hypoxia; isy1 syf2 cells have defective spindles activiating cell cycle arrest