Gene

CRM1

Species
Saccharomyces cerevisiae
Symbol
CRM1
Name
Chromosome Region Maintenance
Synonyms
  • KAP124
  • XPO1
Biotype
protein coding gene
Automated Description
Enables nuclear import signal receptor activity and snRNA binding activity. Involved in mRNA export from nucleus; protein localization to kinetochore; and ribosomal large subunit export from nucleus. Acts upstream of or within protein export from nucleus and tRNA re-export from nucleus. Located in kinetochore; nucleus; and spindle pole body. Human ortholog(s) of this gene implicated in colorectal cancer; gastric adenocarcinoma; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human XPO1 (exportin 1).
SGD Description
Nuclear export factor, exportin; major karyopherin involved in export of proteins, RNAs, and ribosomal subunits from the nucleus
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11223:SF2
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
Viewer Help
933.0k933.5k934.0k934.5k935.0k935.5k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions