Enables nuclear import signal receptor activity and snRNA binding activity. Involved in mRNA export from nucleus; protein localization to kinetochore; and ribosomal large subunit export from nucleus. Acts upstream of or within protein export from nucleus and tRNA re-export from nucleus. Located in kinetochore; nucleus; and spindle pole body. Human ortholog(s) of this gene implicated in colorectal cancer; gastric adenocarcinoma; hepatocellular carcinoma; and lung non-small cell carcinoma. Orthologous to human XPO1 (exportin 1).
SGD Description
Nuclear export factor, exportin; major karyopherin involved in export of proteins, RNAs, and ribosomal subunits from the nucleus