Contributes to 6-phosphofructokinase activity. Involved in glycolytic process and regulation of intracellular pH. Located in mitochondrion. Part of 6-phosphofructokinase complex. Used to study glycogen storage disease. Human ortholog(s) of this gene implicated in glycogen storage disease VII. Orthologous to human PFKL (phosphofructokinase, liver type); PFKM (phosphofructokinase, muscle); and PFKP (phosphofructokinase, platelet).
SGD Description
Alpha subunit of heterooctameric phosphofructokinase; involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes