Gene

FOL2

Species
Saccharomyces cerevisiae
Symbol
FOL2
Name
FOLic acid synthesis
Synonyms
  • YGR267C
Biotype
protein coding gene
Automated Description
Enables GTP cyclohydrolase I activity. Involved in folic acid-containing compound biosynthetic process. Located in nucleus. Used to study dystonia. Human ortholog(s) of this gene implicated in several diseases, including BH4-deficient hyperphenylalaninemia B; diabetic angiopathy; movement disease (multiple); sickle cell anemia; and type 2 diabetes mellitus. Orthologous to human GCH1 (GTP cyclohydrolase 1).
SGD Description
GTP-cyclohydrolase I, catalyzes first step in folic acid biosynthesis; human homolog GCH1 is implicated in dopa-responsive dystonia (DRD), and can complement yeast null mutant
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11109:SF7
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
Viewer Help
1.0251M1.0252M1.0253M1.0254M1.0255M1.0256M1.0257M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions