Gene

CAB4

Species
Saccharomyces cerevisiae
Symbol
CAB4
Name
Coenzyme A Biosynthesis
Synonyms
  • YGR277C
Biotype
protein coding gene
Automated Description
Predicted to enable dephospho-CoA kinase activity and pantetheine-phosphate adenylyltransferase activity. Involved in coenzyme A biosynthetic process. Located in cytoplasm and nucleus. Part of CoA-synthesizing protein complex. Used to study cancer. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III; neurodegeneration with brain iron accumulation 6; and pontocerebellar hypoplasia type 12. Orthologous to human COASY (Coenzyme A synthase).
SGD Description
Subunit of the CoA-Synthesizing Protein Complex (CoA-SPC); subunits of this complex are: Cab2p, Cab3p, Cab4p, Cab5p, Sis2p and Vhs3p; involved in histone acylation; probable pantetheine-phosphate adenylyltransferase (PPAT); PPAT catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT) and by human COASY
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10695:SF54
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
Viewer Help
1.0457M1.0458M1.0459M1.0460M1.0461M1.0462M1.0463M1.0464M1.0465M

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions