Gene

IKS1

Species
Saccharomyces cerevisiae
Symbol
IKS1
Name
Not Available
Synonyms
  • YJL057C
Biotype
protein coding gene
Automated Description
Enables protein kinase activity. Involved in protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease; Huntington's disease; Parkinson's disease; dystonia 33; and hepatitis B. Orthologous to human EIF2AK2 (eukaryotic translation initiation factor 2 alpha kinase 2).
SGD Description
Protein kinase of unknown cellular role; putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11042:SF138
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensEIF2AK23 of 9YesYes   
Mus musculusEif2ak23 of 9YesYes   
Rattus norvegicusEif2ak23 of 9YesYes   
Xenopus tropicalispkr23 of 9YesYes   
Xenopus tropicalissmim183 of 9YesYes   
Xenopus tropicaliseif2ak23 of 9YesYes   
Danio reriosi:ch211-63o20.72 of 9YesYes   
Danio rerioeif2ak22 of 9YesYes   
Danio rerioeif2ak12 of 9YesYes   
Danio reriopdik1l2 of 9YesYes   
Danio reriopkz2 of 9YesYes   
Danio reriostk35l2 of 9YesYes   
Danio reriostk352 of 9YesYes   
Drosophila melanogasterPEK2 of 9YesYes   
Caenorhabditis eleganspek-12 of 9YesYes   
Caenorhabditis elegansY38E10A.82 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
abnormal vacuolar morphology
decreased chronological lifespan
decreased metal resistance
decreased resistance to chemicals
decreased starvation resistance
decreased UV resistance
increased competitive fitness
increased resistance to chemicals
normal competitive fitness
viable
Showing 1 - 10 of 10 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
R64-5-1
Viewer Help
328.2k328.4k328.6k328.8k329.0k329.2k329.4k329.6k329.8k330.0k
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
iks1-Δ
  • iks1-delta
allele
Yes
iks1-G185Dallele
NC_001142.9:g.330001T>Cvariant
SNP
  • missense variant
NC_001142.9:g.329858T>Cvariant
SNP
  • synonymous variant
NC_001142.9:g.328162C>Tvariant
SNP
  • missense variant
NC_001142.9:g.328430A>Gvariant
SNP
  • synonymous variant
NC_001142.9:g.328664A>Gvariant
SNP
  • synonymous variant
NC_001142.9:g.329633C>Tvariant
SNP
  • synonymous variant
NC_001142.9:g.329192G>Avariant
SNP
  • synonymous variant
NC_001142.9:g.328971G>Avariant
SNP
  • missense variant
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Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
Viewer Help
328.2k328.4k328.6k328.8k329.0k329.2k329.4k329.6k329.8k330.0kYJL057C_id001 (IKS1)YJL057C_id003 (IKS1)

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
all annotationsall anatomical structuresalimentary part of gastrointestinal systemchemosensory systemcirculatory systemendocrine systemexocrine systemhemolymphoid systemhepatobiliary systemintegumental systemmechanosensory systemmusculoskeletal systemnervous systemrenal systemreproductive systemrespiratory systemsensory systemvestibulo-auditory systemvisual systemendodermectodermmesodermmesenchymeadipose tissueappendageentire extraembryonic componentimaginal precursorpharyngeal archotherall stagesembryo stagepost embryonic, pre-adultpost-juvenile adult stageall cellular componentsextracellular regionplasma membranesynapsecell junctioncell projectioncytoplasmic vesicleendosomevacuolegolgi apparatusendoplasmic reticulumcytosolmitochondrionnucleuschromosomecytoskeletonprotein-containing complexother locations
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

157 interactor genes based on 164 annotations
IKS1 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
ACL4Saccharomyces cerevisiae
protein
  • pull down
PMID:21460040
protein
ALA1Saccharomyces cerevisiae
protein
  • pull down
PMID:21460040
protein
AVO1Saccharomyces cerevisiae
protein
  • enzymatic study
PMID:16319894
RNA
CCR4Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:29158339
protein
CDC5Saccharomyces cerevisiae
protein
  • two hybrid
PMID:17634282
protein
CDC11Saccharomyces cerevisiae
protein
  • pull down
PMID:21460040
protein
CDC15Saccharomyces cerevisiae
protein
  • enzymatic study
PMID:16319894
protein
CLC1Saccharomyces cerevisiae
protein
  • pull down
PMID:21460040
protein
CMR3Saccharomyces cerevisiae
protein
  • enzymatic study
PMID:16319894
protein
CPR7Saccharomyces cerevisiae
protein
  • pull down
PMID:21460040
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Genetic Interactions

IKS1 role
IKS1 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
unspecified role
ASK10Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
ATP7Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
ATP10Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
ATP18Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
BCK1Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:19269370
unspecified role
BIR1Saccharomyces cerevisiae
unspecified role
positive genetic interaction (sensu BioGRID)
  • fitness
PMID:28754723
unspecified role
BRE5Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
unspecified role
BUB1Saccharomyces cerevisiae
unspecified role
positive genetic interaction (sensu BioGRID)
  • colony size
  • resistance to chemicals
PMID:21127252
unspecified role
CDC28Saccharomyces cerevisiae
unspecified role
dosage lethality (sensu BioGRID)
  • inviable
PMID:28428242
unspecified role
CEP3Saccharomyces cerevisiae
unspecified role
negative genetic interaction (sensu BioGRID)
  • colony size
PMID:27708008
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