Enables protein kinase binding activity. Contributes to ATP hydrolysis activity. Involved in DNA recombination; G2/M transition of mitotic cell cycle; and chromosome organization. Located in nucleus. Part of mitotic cohesin complex. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 3; hepatocellular carcinoma; and intellectual disability. Orthologous to human SMC3 (structural maintenance of chromosomes 3).
SGD Description
Subunit of the multiprotein cohesin complex; required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member