Gene

SMC3

Species
Saccharomyces cerevisiae
Symbol
SMC3
Name
Stability of MiniChromosomes
Synonyms
  • YJL074C
Biotype
protein coding gene
Automated Description
Enables protein kinase binding activity. Contributes to ATP hydrolysis activity. Involved in DNA recombination; G2/M transition of mitotic cell cycle; and chromosome organization. Located in nucleus. Part of mitotic cohesin complex. Human ortholog(s) of this gene implicated in Cornelia de Lange syndrome 3; hepatocellular carcinoma; and intellectual disability. Orthologous to human SMC3 (structural maintenance of chromosomes 3).
SGD Description
Subunit of the multiprotein cohesin complex; required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43977:SF1
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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299.5k300.0k300.5k301.0k301.5k302.0k302.5k

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions