Involved in cellular response to misfolded protein. Located in mitochondrial outer membrane and nucleus. Orthologous to several human genes including TTC39B (tetratricopeptide repeat domain 39B).
SGD Description
Protein required for clearance of inclusion bodies; localizes to the inclusion bodies formed under protein misfolding stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; IML2 has a paralog, YKR018C, that arose from the whole genome duplication