Gene

TRL1

Species
Saccharomyces cerevisiae
Symbol
TRL1
Name
tRNA Ligase
Synonyms
  • LIG1
  • RLG1
Biotype
protein coding gene
Automated Description
Enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity; GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity; and RNA ligase (ATP) activity. Involved in IRE1-mediated unfolded protein response; regulation of gene expression; and tRNA splicing, via endonucleolytic cleavage and ligation. Acts upstream of or within nuclear-transcribed mRNA catabolic process, no-go decay. Located in cytoplasm and nuclear inner membrane.
SGD Description
tRNA ligase; required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; involved in turnover of tRNA introns; localized at the inner nuclear envelope and cytoplasm
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR32004:SF1
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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270.2k270.4k270.6k270.8k271.0k271.2k271.4k271.6k271.8k272.0k272.2k272.4k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions