Enables 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity; GTP-dependent polyribonucleotide 5'-hydroxyl-kinase activity; and RNA ligase (ATP) activity. Involved in IRE1-mediated unfolded protein response; regulation of gene expression; and tRNA splicing, via endonucleolytic cleavage and ligation. Acts upstream of or within nuclear-transcribed mRNA catabolic process, no-go decay. Located in cytoplasm and nuclear inner membrane.
SGD Description
tRNA ligase; required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; involved in turnover of tRNA introns; localized at the inner nuclear envelope and cytoplasm