Species

Saccharomyces cerevisiae

Symbol

TPK1

Name

Takashi's Protein Kinase

Synonyms

PKA1
SRA3

Biotype

protein coding gene

Automated Description

Enables cAMP-dependent protein kinase activity. Involved in several processes, including intracellular signal transduction; negative regulation of cytoplasmic mRNA processing body assembly; and protein import into nucleus. Located in chromatin; cytoplasm; and nucleus. Part of cAMP-dependent protein kinase complex. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; fibrolamellar carcinoma; platelet-type bleeding disorder 19; and primary pigmented nodular adrenocortical disease 4. Orthologous to several human genes including PRKACA (protein kinase cAMP-activated catalytic subunit alpha); PRKACB (protein kinase cAMP-activated catalytic subunit beta); and PRKACG (protein kinase cAMP-activated catalytic subunit gamma).

SGD Description

cAMP-dependent protein kinase catalytic subunit; role in nutrient-stimulated growth via Ras-cAMP signaling; inhibited by regulatory subunit Bcy1p in cAMPs absence; phosphorylates and inhibits Whi3p to promote G1/S phase passage; phosphorylates Nej1p to regulate nonhomologous end joining (NHEJ); impairs mitochondrial import of pre-Tom40p via phosphorylation under non-respiratory conditions; partially redundant with Tpk2p and Tpk3p; human homolog PRKACB regulates NHEJ via NHEJ1 phosphorylation

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR24353:SF73

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Show functions with at least one experimental evidence

Pathways

No data available

Phenotypes

Primary Sources

SGD

Other Sources

None

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Disease Associations

Include negative annotationsCases where the expected disease association was NOT found

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No data available

Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Download all Alleles/Variants for all genes of the species

Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

Model name	Experimental condition	Associated Human Diseases	Associated Phenotypes	Modifier	Source
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Sequence Feature Viewer

Genome location

ChrX:109966...111159 - (1.19 kb)

Assembly version

R64-5-1

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Data currently unavailable; sequence viewer under construction

Sequence Details

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Expression

Primary Sources

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

TPK1 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
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Genetic Interactions

TPK1 role	TPK1 genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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