Gene

BNA2

Species
Saccharomyces cerevisiae
Symbol
BNA2
Name
Biosynthesis of Nicotinic Acid
Synonyms
  • YJR078W
Biotype
protein coding gene
Automated Description
Enables indoleamine 2,3-dioxygenase activity. Involved in 'de novo' NAD biosynthetic process from tryptophan. Located in cytoplasm. Orthologous to human IDO1 (indoleamine 2,3-dioxygenase 1) and IDO2 (indoleamine 2,3-dioxygenase 2).
SGD Description
Tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase; required for de novo biosynthesis of NAD+ from tryptophan via kynurenine; up-regulated by telomere uncapping, and interacts genetically with capping gene CDC13; overexpression reduces lipid droplet accumulation by skewing glycolytic flux towards biosynthesis of shikimate, aromatic amino acids, and NAD+ during aging and extends lifespan; regulated by Hst1p and Aftp
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR28657:SF5
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
Viewer Help
579.0k579.2k579.4k579.6k579.8k580.0k580.2k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions