Enables indoleamine 2,3-dioxygenase activity. Involved in 'de novo' NAD biosynthetic process from tryptophan. Located in cytoplasm. Orthologous to human IDO1 (indoleamine 2,3-dioxygenase 1) and IDO2 (indoleamine 2,3-dioxygenase 2).
SGD Description
Tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase; required for de novo biosynthesis of NAD+ from tryptophan via kynurenine; up-regulated by telomere uncapping, and interacts genetically with capping gene CDC13; overexpression reduces lipid droplet accumulation by skewing glycolytic flux towards biosynthesis of shikimate, aromatic amino acids, and NAD+ during aging and extends lifespan; regulated by Hst1p and Aftp