Gene

SMF3

Species
Saccharomyces cerevisiae
Symbol
SMF3
Name
Not Available
Synonyms
  • YLR034C
Biotype
protein coding gene
Automated Description
Predicted to enable cadmium ion transmembrane transporter activity and manganese ion transmembrane transporter activity. Involved in intracellular iron ion homeostasis and iron ion transport. Located in fungal-type vacuole membrane. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); autoimmune disease (multiple); inflammatory bowel disease (multiple); leishmaniasis (multiple); and tuberculosis (multiple). Orthologous to human SLC11A1 (solute carrier family 11 member 1) and SLC11A2 (solute carrier family 11 member 2).
SGD Description
Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of Nramp family of metal transport proteins; targeted to vacuole via AP-3 pathway; protein abundance increases in response to DNA replication stress
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11706:SF29
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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210.6k210.8k211.0k211.2k211.4k211.6k211.8k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions