Gene

DPH6

Species
Saccharomyces cerevisiae
Symbol
DPH6
Name
DiPHthamide biosynthesis
Synonyms
  • YLR143W
Biotype
protein coding gene
Automated Description
Enables diphthine-ammonia ligase activity. Involved in protein histidyl modification to diphthamide. Located in cytoplasm. Orthologous to human DPH6 (diphthamine biosynthesis 6).
SGD Description
Diphthamide synthetase; catalyzes the last amidation step of diphthamide biosynthesis using ammonium and ATP; evolutionarily conserved in eukaryotes; dph6 mutants exhibit diphthine accumulation and resistance to sordarin, which is indicative of defects in diphthamide formation on EF2; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; DPH6/YLR143W is not an essential gene
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12196:SF2
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions