Version: 8.0.0Date: Tue Jan 28 2025
Gene
TUB4
- Species
- Saccharomyces cerevisiae
- Symbol
- TUB4
- Name
- TUBulin
- Synonyms
- YLR212C
- Biotype
- protein coding gene
- Automated Description
- A structural constituent of cytoskeleton. Involved in microtubule nucleation by spindle pole body; mitotic spindle organization; and positive regulation of cytoplasmic translation. Located in inner plaque of spindle pole body and outer plaque of spindle pole body. Part of gamma-tubulin small complex. Used to study complex cortical dysplasia with other brain malformations 4. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 4; inclusion body myositis; and muscular disease. Orthologous to several human genes including TUBG2 (tubulin gamma 2).
- SGD Description
- Gamma-tubulin; involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body; protein abundance increases in response to DNA replication stress; null mutation is complemented by human TUBG1
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR11588:SF7
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Sequence Feature Viewer
- Genome location
- ChrXII:564860...566281 - (1.42 kb)
- Assembly version
- R64-5-1
- Viewer Help
Data currently unavailable; sequence viewer under construction