Gene

SFH1

Species
Saccharomyces cerevisiae
Symbol
SFH1
Name
Snf Five Homolog
Synonyms
  • YLR321C
Biotype
protein coding gene
Automated Description
Enables nucleosome binding activity. Involved in several processes, including chromatin remodeling; regulation of nuclear cell cycle DNA replication; and transcription elongation by RNA polymerase II. Part of RSC-type complex. Human ortholog(s) of this gene implicated in Coffin-Siris syndrome 3; meningioma; rhabdoid cancer; rhabdoid tumor predisposition syndrome 1; and schwannomatosis (multiple). Orthologous to human SMARCB1 (SWI/SNF related BAF chromatin remodeling complex subunit B1).
SGD Description
Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog; hSNF5 tumor suppressor ortholog
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10019:SF5
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensSMARCB15 of 9YesYes   
Mus musculusSmarcb15 of 9YesYes   
Rattus norvegicusSmarcb15 of 9YesYes   
Xenopus tropicalissmarcb15 of 9YesYes   
Danio reriosmarcb1b5 of 9YesYes   
Danio reriosmarcb1a5 of 9YesYes   
Drosophila melanogasterSnr15 of 9YesYes   
Caenorhabditis eleganssnfc-55 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
abnormal protein/peptide distribution
arrested cell cycle progression through the G2/M phase transition
decreased resistance to chemicals
decreased size of nucleolus
decreased starvation resistance
haploproficient
increased competitive fitness
increased heat sensitivity
increased innate thermotolerance
inviable
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
Viewer Help
776.6k776.8k777.0k777.2k777.4k777.6k777.8k

Sequence Details

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Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions