Version: 8.0.0
Date: Tue Jan 28 2025
ELO3
Saccharomyces cerevisiaeSGD:S000004364
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

ELO3

Species
Saccharomyces cerevisiae
Symbol
ELO3
Name
fatty acid ELOngation
Synonyms
  • APA1
  • SRE1
Biotype
protein coding gene
Automated Description
Enables fatty acid elongase activity. Involved in late endosome to vacuole transport via multivesicular body sorting pathway; lipid biosynthetic process; and post-Golgi vesicle-mediated transport. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in corneal dystrophy; spinocerebellar ataxia type 34; and spinocerebellar ataxia type 38. Orthologous to several human genes including ELOVL1 (ELOVL fatty acid elongase 1) and ELOVL4 (ELOVL fatty acid elongase 4).
SGD Description
Elongase; involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis; lethality of the elo2 elo3 double null mutation is functionally complemented by human ELOVL1 and weakly complemented by human ELOVL3 or ELOV7
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11157:SF157
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R64-5-1
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          ELO3 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            ELO3 role
            ELO3 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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