Enables fructose 1,6-bisphosphate 1-phosphatase activity. Involved in gluconeogenesis and reactive oxygen species metabolic process. Located in cytosol and periplasmic space. Human ortholog(s) of this gene implicated in fructose-1,6-bisphosphatase deficiency. Orthologous to human FBP1 (fructose-bisphosphatase 1) and FBP2 (fructose-bisphosphatase 2).
SGD Description
Fructose-1,6-bisphosphatase; key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; glucose starvation results in redistribution to the periplasm; interacts with Vid30p