Gene

FBP1

Species
Saccharomyces cerevisiae
Symbol
FBP1
Name
Fructose-1,6-BisPhosphatase
Synonyms
  • ACN8
  • YLR377C
Biotype
protein coding gene
Automated Description
Enables fructose 1,6-bisphosphate 1-phosphatase activity. Involved in gluconeogenesis and reactive oxygen species metabolic process. Located in cytosol and periplasmic space. Human ortholog(s) of this gene implicated in fructose-1,6-bisphosphatase deficiency. Orthologous to human FBP1 (fructose-bisphosphatase 1) and FBP2 (fructose-bisphosphatase 2).
SGD Description
Fructose-1,6-bisphosphatase; key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; glucose starvation results in redistribution to the periplasm; interacts with Vid30p
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11556:SF1
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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873.8k873.9k874.0k874.1k874.2k874.3k874.4k874.5k874.6k874.7k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions