Gene

NAM2

Species
Saccharomyces cerevisiae
Symbol
NAM2
Name
Nuclear Accommodation of Mitochondria
Synonyms
  • LeuRS
  • MSL1
Biotype
protein coding gene
Automated Description
Enables leucine-tRNA ligase activity and pre-mRNA intronic binding activity. Involved in Group I intron splicing; leucyl-tRNA aminoacylation; and mitochondrial translation. Located in mitochondrion. Used to study Perrault syndrome and mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human LARS2 (leucyl-tRNA synthetase 2, mitochondrial).
SGD Description
Mitochondrial leucyl-tRNA synthetase; also has direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance; human homolog LARS2 can complement yeast null mutant, and is implicated in Perrault syndrome
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43740:SF2
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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882.5k883.0k883.5k884.0k884.5k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions