Enables leucine-tRNA ligase activity and pre-mRNA intronic binding activity. Involved in Group I intron splicing; leucyl-tRNA aminoacylation; and mitochondrial translation. Located in mitochondrion. Used to study Perrault syndrome and mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human LARS2 (leucyl-tRNA synthetase 2, mitochondrial).
SGD Description
Mitochondrial leucyl-tRNA synthetase; also has direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance; human homolog LARS2 can complement yeast null mutant, and is implicated in Perrault syndrome