Gene

SIR3

Species
Saccharomyces cerevisiae
Symbol
SIR3
Name
Silent Information Regulator
Synonyms
  • CMT1
  • MAR2
Biotype
protein coding gene
Automated Description
Enables DNA replication origin binding activity; nucleosome binding activity; and single-stranded DNA binding activity. Involved in several processes, including double-strand break repair via nonhomologous end joining; establishment of protein-containing complex localization to telomere; and negative regulation of macromolecule metabolic process. Located in chromosome, telomeric region; heterochromatin; and nucleolus. Part of chromatin silencing complex. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 1. Orthologous to human ORC1 (origin recognition complex subunit 1).
SGD Description
Silencing protein; interacts with Sir2p, Sir4p, and histone H3/H4 tails to establish transcriptionally silent chromatin; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p; C-terminus assumes variant winged helix-turn-helix (wH) fold that mediates homodimerization, which is critical for holo-SIR complex loading; required for telomere hypercluster formation in quiescent yeast cells; has paralog ORC1 from whole genome duplication
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10763:SF23
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Homo sapiensORC13 of 9YesNo   
Rattus norvegicusOrc13 of 9YesNo   
Xenopus tropicalisorc15 of 9YesNo   
Danio rerioorc14 of 9YesNo   
Drosophila melanogasterOrc14 of 9YesNo   
Caenorhabditis elegansorc-13 of 9YesNo   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
ORC11103545278 of 9 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
abnormal chemical compound accumulation
abnormal colony appearance
abnormal liquid culture appearance
abnormal meiosis
abnormal protein/peptide distribution
abnormal vacuolar morphology
absent mating response
absent pheromone sensitivity
absent pheromone-induced cell cycle arrest
absent respiratory growth
Showing 1 - 10 of 31 rows
per page

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
R64-5-1
Viewer Help
1.0195M1.0200M1.0205M1.0210M1.0215M1.0220M
Variant Types and ConsequencesOnly variants associated to alleles are shown in the graphics above. See all variants in JBrowse.
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
sir3-D205Nallele
sir3-S67Pallele
sir3-E137Gallele
sir3-L738Pallele
sir3-A136Vallele
sir3-P179Lallele
sir3-A2Qallele
Yes
sir3-Δbah
  • sir3-bahΔ
allele
sir3-(ste8-T2E,S3E,S7E)
  • ste8-T2E,S3E,S7E
allele
sir3-1021
  • sir3-D640A, S642L
allele
Showing 1 - 10 of 95 rows
per page

Transgenic Alleles

No data available

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
Viewer Help
1.0195M1.0200M1.0205M1.0210M1.0215M1.0220MYLR442C_id001 (SIR3)YLR442C_id002 (SIR3)

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

131 interactor genes based on 402 annotations
SIR3 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
ACO1Saccharomyces cerevisiae
protein
  • cross-linking study
PMID:32051233
protein
ADH6Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:11805837
protein
APJ1Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:32492414
protein
ARP9Saccharomyces cerevisiae
protein
  • pull down
PMID:25453095
protein
ASF2Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:18794362
protein
ASF2Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:37968396
protein
BDF1Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:37968396
RNA
CCR4Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:29158339
protein
CHZ1Saccharomyces cerevisiae
protein
  • imaging technique
PMID:20008511
protein
COR1Saccharomyces cerevisiae
protein
  • affinity chromatography technology
PMID:11805837
Showing 1 - 10 of 272 rows
per page

Genetic Interactions

SIR3 role
SIR3 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
unspecified role
ACS2Saccharomyces cerevisiae
unspecified role
synthetic growth defect (sensu BioGRID)
  • vegetative growth
PMID:18676811
enhanced gene
ARP5Saccharomyces cerevisiae
enhancer gene
phenotypic enhancement (sensu BioGRID)
  • chromosome/plasmid maintenance
PMID:25691465
unspecified role
CDC6Saccharomyces cerevisiae
unspecified role
synthetic rescue (sensu BioGRID)
  • heat sensitivity, partial rescue
PMID:15082529
unspecified role
CDC6Saccharomyces cerevisiae
unspecified role
synthetic rescue (sensu BioGRID)
  • heat sensitivity, partial rescue
PMID:29795547
unspecified role
CDC28Saccharomyces cerevisiae
unspecified role
synthetic growth defect (sensu BioGRID)
  • vegetative growth
PMID:22689984
enhancer gene
CDC73Saccharomyces cerevisiae
enhanced gene
phenotypic enhancement (sensu BioGRID)
  • mutation frequency
PMID:29320491
unspecified role
CNB1Saccharomyces cerevisiae
unspecified role
synthetic growth defect (sensu BioGRID)
  • vegetative growth
PMID:21712379
unspecified role
CSM3Saccharomyces cerevisiae
unspecified role
synthetic rescue (sensu BioGRID)
  • resistance to chemicals
PMID:28389464
suppressed gene
DNL4Saccharomyces cerevisiae
suppressor gene
phenotypic suppression (sensu BioGRID)
  • chromosome/plasmid maintenance
PMID:34817085
unspecified role
DOT1Saccharomyces cerevisiae
unspecified role
synthetic rescue (sensu BioGRID)
  • resistance to chemicals, wild type
PMID:18562671
Showing 1 - 10 of 130 rows
per page