Gene

HMG2

Species
Saccharomyces cerevisiae
Symbol
HMG2
Name
3-Hydroxy-3-MethylGlutaryl-coenzyme a reductase
Synonyms
  • YLR450W
Biotype
protein coding gene
Automated Description
Enables hydroxymethylglutaryl-CoA reductase (NADPH) activity. Involved in ergosterol biosynthetic process. Located in endoplasmic reticulum membrane and nuclear envelope. Part of proteasome complex. Is active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; coronary artery disease (multiple); diabetes mellitus (multiple); muscular disease (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase).
SGD Description
HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at nuclear periphery upon DNA replication stress; primarily expressed on the peri-membrane side of the ER; human homolog HMGCR can complement yeast hmg2 mutant
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10572:SF24
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
Viewer Help
1.0330M1.0335M1.0340M1.0345M1.0350M1.0355M

Sequence Details

Loading...

Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions