Version: 8.0.0Date: Tue Jan 28 2025
Gene
CCS1
- Species
- Saccharomyces cerevisiae
- Symbol
- CCS1
- Name
- Copper Chaperone for SOD1
- Synonyms
- CCS
- LYS7
- Biotype
- protein coding gene
- Automated Description
- Enables superoxide dismutase copper chaperone activity. Involved in protein maturation by copper ion transfer. Located in cytosol; mitochondrial inner membrane; and nucleus. Used to study amyotrophic lateral sclerosis; cataract; neurodegenerative disease; and sensorineural hearing loss. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human CCS (copper chaperone for superoxide dismutase).
- SGD Description
- Copper chaperone for superoxide dismutase Sod1p; involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within N-terminus is involved in insertion of copper into Sod1p under conditions of copper deprivation; required for regulation of yeast copper genes in response to DNA-damaging agents; protein abundance increases in response to DNA replication stress; human homolog CCS can complement yeast ccs1 null mutant
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR10003:SF86
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrXIII:347511...348260 - (0.75 kb)
- Assembly version
- R64-5-1
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.