Gene

TOM40

Species
Saccharomyces cerevisiae
Symbol
TOM40
Name
Translocase of the Outer Mitochondrial membrane
Synonyms
  • ISP42
  • MOM38
Biotype
protein coding gene
Automated Description
Enables protein transmembrane transporter activity. Involved in protein import into mitochondrial matrix. Located in mitochondrial outer membrane. Part of mitochondrial outer membrane translocase complex. Human ortholog(s) of this gene implicated in cerebral infarction. Orthologous to human TOMM40 (translocase of outer mitochondrial membrane 40) and TOMM40L (translocase of outer mitochondrial membrane 40 like).
SGD Description
Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore; pre-Tom40p is phosphorylated by PKA, which impairs its import into mitochondria under non-respiratory conditions
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10802:SF2
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
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      Alleles and Variants

      Allele/Variant Symbol
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      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R64-5-1
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            668.6k668.8k669.0k669.2k669.4k669.6k

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            TOM40 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              TOM40 role
              TOM40 genetic perturbation
              Interactor gene
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