Gene

TOM40

Species
Saccharomyces cerevisiae
Symbol
TOM40
Name
Translocase of the Outer Mitochondrial membrane
Synonyms
  • ISP42
  • MOM38
Biotype
protein coding gene
Automated Description
Enables protein transmembrane transporter activity. Involved in protein import into mitochondrial matrix. Located in mitochondrial outer membrane. Part of mitochondrial outer membrane translocase complex. Human ortholog(s) of this gene implicated in cerebral infarction. Orthologous to human TOMM40 (translocase of outer mitochondrial membrane 40) and TOMM40L (translocase of outer mitochondrial membrane 40 like).
SGD Description
Component of the TOM (translocase of outer membrane) complex; responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore; pre-Tom40p is phosphorylated by PKA, which impairs its import into mitochondria under non-respiratory conditions
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10802:SF2
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
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    Transgenic Alleles

    Models

    Sequence Feature Viewer

    Genome location
    Assembly version
    R64-5-1
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    668.6k668.8k669.0k669.2k669.4k669.6k

    Sequence Details

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    Expression

    Primary Sources
    Other Sources
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    Genetic Interactions