Gene

SIS1

Species
Saccharomyces cerevisiae
Symbol
SIS1
Name
SIt4 Suppressor
Synonyms
  • YNL007C
Biotype
protein coding gene
Automated Description
Enables misfolded protein binding activity. Involved in several processes, including detection of misfolded protein; gene expression; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in nucleus. Part of cytosolic small ribosomal subunit. Is active in cytosol and nucleolus. Used to study autosomal dominant limb-girdle muscular dystrophy type 1 and congenital myopathy 21. Human ortholog(s) of this gene implicated in congenital myopathy 21 and primary ciliary dyskinesia 34. Orthologous to several human genes including DNAJB1 (DnaJ heat shock protein family (Hsp40) member B1).
SGD Description
Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; shuttles between cytosol and nucleus; mediates delivery of misfolded proteins into the nucleus for degradation; involved in proteasomal degradation of misfolded cytosolic proteins; protein abundance increases in response to DNA replication stress; polyQ aggregates sequester Sis1p and interfere with clearance of misfolded proteins; similar to bacterial DnaJ proteins and mammalian DnaJB1
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24078:SF519
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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618.6k618.7k618.8k618.9k619.0k619.1k619.2k619.3k619.4k619.5k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions