Version: 8.0.0
Date: Tue Jan 28 2025
YNL040W
Saccharomyces cerevisiaeSGD:S000004985
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

YNL040W

Species
Saccharomyces cerevisiae
Symbol
YNL040W
Name
Not Available
Synonyms
  • YNL040W
Biotype
protein coding gene
Automated Description
Enables L-seryl-tRNA(Thr) hydrolase activity and Ser-tRNA(Ala) hydrolase activity. Involved in aminoacyl-tRNA metabolism involved in translational fidelity. Located in cytoplasm. Orthologous to human PTGES3L-AARSD1 (PTGES3L-AARSD1 readthrough) and AARSD1 (alanyl-tRNA synthetase domain containing 1).
SGD Description
Ser-tRNA(Ala) hydrolase; hydrolyzes Ser-mischarged cytoplasmic and mitochondrial tRNAs; regulates translational fidelity based on Ala- and Thr-to-Ser misincorporation in the null mutant; trans-editing factor for alanyl- and threonyl-tRNA synthetases and seryl-tRNA synthetase (SerRS) via hydrolysis; null mutant displays decreased translation rate and increased readthrough of premature stop codons; (GFP)-fusion protein localizes to the cytoplasm; homologous to human trans-editing factor AARSD
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43462:SF1
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
    Evidence
    Source
    Based On
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
      Has Disease Annotations
      Has Phenotype Annotations
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
        Has Disease Annotations
        Has Phenotype Annotations
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          Models

          Model name
          Experimental condition
          Associated Human Diseases
          Associated Phenotypes
          Modifier
          Source
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            Sequence Feature Viewer

            Genome location
            Assembly version
            R64-5-1
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            553.4k553.6k553.8k554.0k554.2k554.4k554.6k

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            YNL040W molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
            Reference
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              Genetic Interactions

              YNL040W role
              YNL040W genetic perturbation
              Interactor gene
              Interactor species
              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
              Source
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