Gene

ATG2

Species
Saccharomyces cerevisiae
Symbol
ATG2
Name
AuTophaGy related
Synonyms
  • APG2
  • AUT8
Biotype
protein coding gene
Automated Description
Enables phosphatidylinositol-3-phosphate binding activity. Involved in autophagy of mitochondrion; cytoplasm to vacuole targeting by the Cvt pathway; and macroautophagy. Located in phagophore and phagophore assembly site. Orthologous to human ATG2A (autophagy related 2A) and ATG2B (autophagy related 2B).
SGD Description
Putative lipid transport protein; peripheral membrane protein required for vesicle formation during autophagy, pexophagy and the CVT pathway; directed to autophagic membranes by Atg18p where it acts as a PAS-ER membrane tether during autophagosome formation; involved in Atg9p cycling between the PAS and mitochondria; binds the phospholipid PI(3)P via an APT1 domain; essential for cell cycle progression from G2/M to G1 under nitrogen starvation; forms cytoplasmic foci upon DNA replication stress
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13190:SF1
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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191.5k192.0k192.5k193.0k193.5k194.0k194.5k195.0k195.5k196.0k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions