Gene

NUF2

Species
Saccharomyces cerevisiae
Symbol
NUF2
Name
NUclear Filament-containing protein
Synonyms
  • YOL069W
Biotype
protein coding gene
Automated Description
Contributes to microtubule binding activity. Involved in chromosome segregation. Located in kinetochore; spindle microtubule; and spindle pole body. Part of Ndc80 complex. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma and pancreatic cancer. Orthologous to human NUF2 (NUF2 component of NDC80 kinetochore complex).
SGD Description
Component of the kinetochore-associated Ndc80 complex; involved in chromosome segregation, spindle checkpoint activity, and kinetochore clustering; evolutionarily conserved; other members include Ndc80p, Nuf2p, Spc24p, and Spc25p
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR21650:SF2
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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199.0k199.2k199.4k199.6k199.8k200.0k200.2k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions