Enables protein-macromolecule adaptor activity. Contributes to ubiquitin-protein transferase activity. Involved in G1/S transition of mitotic cell cycle and SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Part of Cul3-RING ubiquitin ligase complex; Cul8-RING ubiquitin ligase complex; and SCF ubiquitin ligase complex. Used to study cancer. Orthologous to human RBX1 (ring-box 1).
SGD Description
RING-H2 domain core subunit of multiple ubiquitin ligase complexes; subunit of Skp1-Cullin-F-box (SCF) that tethers the Cdc34p (E2) and Cdc53p (cullin) SCF subunits, and is required for degradation of Gic2p, Far1p, Sic1p and Cln2p; subunit of the Rtt101p-Mms1p-Mms22p ubiquitin ligase that stabilizes replication forks after DNA lesions; subunit of the Cul3p-Elc1p-Ela1p ubiquitin ligase involved in Rpb1p degradation as part of transcription-coupled repair