Gene

HRT1

Species
Saccharomyces cerevisiae
Symbol
HRT1
Name
High level expression Reduces Ty3 transposition
Synonyms
  • HRT2
  • RBX1
Biotype
protein coding gene
Automated Description
Enables protein-macromolecule adaptor activity. Contributes to ubiquitin-protein transferase activity. Involved in G1/S transition of mitotic cell cycle and SCF-dependent proteasomal ubiquitin-dependent protein catabolic process. Located in cytoplasm and nucleus. Part of Cul3-RING ubiquitin ligase complex; Cul8-RING ubiquitin ligase complex; and SCF ubiquitin ligase complex. Used to study cancer. Orthologous to human RBX1 (ring-box 1).
SGD Description
RING-H2 domain core subunit of multiple ubiquitin ligase complexes; subunit of Skp1-Cullin-F-box (SCF) that tethers the Cdc34p (E2) and Cdc53p (cullin) SCF subunits, and is required for degradation of Gic2p, Far1p, Sic1p and Cln2p; subunit of the Rtt101p-Mms1p-Mms22p ubiquitin ligase that stabilizes replication forks after DNA lesions; subunit of the Cul3p-Elc1p-Ela1p ubiquitin ligase involved in Rpb1p degradation as part of transcription-coupled repair
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11210:SF2
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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70.35k70.40k70.45k70.50k70.55k70.60k70.65k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions