Version: 8.0.0
Date: Tue Jan 28 2025
OST3
Saccharomyces cerevisiaeSGD:S000005611
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

OST3

Species
Saccharomyces cerevisiae
Symbol
OST3
Name
OligoSaccharylTransferase
Synonyms
  • YOR085W
Biotype
protein coding gene
Automated Description
Enables dolichyl-diphosphooligosaccharide-protein glycotransferase activity and protein-disulfide reductase activity. Involved in protein N-linked glycosylation and protein O-linked mannosylation. Located in membrane. Part of oligosaccharyltransferase complex. Human ortholog(s) of this gene implicated in X-linked immunodeficiency with magnesium defect, Epstein-Barr virus infection, and neoplasia; autosomal recessive intellectual developmental disorder 7; and congenital disorder of glycosylation Icc. Orthologous to human MAGT1 (magnesium transporter 1) and TUSC3 (tumor suppressor candidate 3).
SGD Description
Gamma subunit of the oligosaccharyltransferase complex of the ER lumen; complex catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins including modification of Pmt2p at N131 and N403
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12692:SF0
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          R64-5-1
          Viewer Help
          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          OST3 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            OST3 role
            OST3 genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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