Version: 8.0.0Date: Tue Jan 28 2025
Gene
DED1
- Species
- Saccharomyces cerevisiae
- Symbol
- DED1
- Name
- Defines Essential Domain
- Synonyms
- SPP81
- YOR204W
- Biotype
- protein coding gene
- Automated Description
- Enables RNA helicase activity; eukaryotic initiation factor 4G binding activity; and nucleic acid binding activity. Involved in positive regulation of formation of translation preinitiation complex; spliceosomal complex disassembly; and translational initiation. Located in cytoplasmic stress granule and nucleus. Used to study childhood medulloblastoma. Human ortholog(s) of this gene implicated in colorectal cancer and syndromic X-linked intellectual disability. Orthologous to human DDX3X (DEAD-box helicase 3 X-linked) and DDX3Y (DEAD-box helicase 3 Y-linked).
- SGD Description
- ATP-dependent DEAD-box RNA helicase with strand-annealing activity; promotes eIF4F-dependent 48S translation preinitiation complex (PIC) assembly, stimulating recruitment of mRNAs with long, structured 5'-UTRs; cooperates with Dbp1p in PIC attachment and scanning; ATPase activity stimulated by mRNA cap-associated factor binding; directly binds eIF4G; role in spliceosomal complex disassembly; mutation in human homolog DBY associated with male infertility; human homolog DDX3X complements the null
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR47958:SF32
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- Other Sources
- None
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- ChrXV:722911...724725 + (1.81 kb)
- Assembly version
- R64-5-1
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.