Enables oxysterol binding activity and sterol transfer activity. Involved in several processes, including maintenance of cell polarity; piecemeal microautophagy of the nucleus; and sterol transport. Located in cellular bud neck and fungal-type vacuole membrane. Orthologous to several human genes including OSBPL11 (oxysterol binding protein like 11).
SGD Description
Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP); SWAT-GFP and mCherry fusion proteins localize to the bud neck and vacuolar membrane; HES1 has a paralog, KES1, that arose from the whole genome duplication