Gene

RRS1

Species
Saccharomyces cerevisiae
Symbol
RRS1
Name
Regulator of Ribosome Synthesis
Synonyms
  • YOR294W
Biotype
protein coding gene
Automated Description
Involved in endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); ribosomal large subunit biogenesis; and ribosomal large subunit export from nucleus. Located in nuclear periphery; nucleolus; and nucleoplasm. Part of preribosome, large subunit precursor. Used to study Huntington's disease and papillary thyroid carcinoma. Orthologous to human RRS1 (ribosome biogenesis regulator 1 homolog).
SGD Description
Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate telomere clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR17602:SF4
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
Viewer Help
868.4k868.5k868.6k868.7k868.8k868.9k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions