Gene

ALD6

Species
Saccharomyces cerevisiae
Symbol
ALD6
Name
ALdehyde Dehydrogenase
Synonyms
  • ALD1
  • YPL061W
Biotype
protein coding gene
Automated Description
Enables aldehyde dehydrogenase [NAD(P)+] activity. Involved in NADPH regeneration; acetate biosynthetic process; and response to salt stress. Located in cytosol and mitochondrion. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; alcohol use disorder; artery disease (multiple); diabetes mellitus (multiple); and liver disease (multiple). Orthologous to several human genes including ALDH1A1 (aldehyde dehydrogenase 1 family member A1); ALDH1A2 (aldehyde dehydrogenase 1 family member A2); and ALDH1A3 (aldehyde dehydrogenase 1 family member A3).
SGD Description
Cytosolic aldehyde dehydrogenase; activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; localizes to the mitochondrial outer surface upon oxidative stress; negative regulator of nonselective autophagy; Stb5p directly regulates the expression of ALD6 mRNA and directly binds to the ALD6 promoter
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11699:SF268
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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432.6k432.8k433.0k433.2k433.4k433.6k433.8k434.0k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions