Gene

GLR1

Species
Saccharomyces cerevisiae
Symbol
GLR1
Name
GLutathione Reductase
Synonyms
  • LPG17
  • YPL091W
Biotype
protein coding gene
Automated Description
Enables glutathione-disulfide reductase (NADPH) activity. Involved in several processes, including cell redox homeostasis; glutathione metabolic process; and protein glutathionylation. Located in cytosol; nucleus; and peroxisome. Used to study limb-girdle muscular dystrophy. Human ortholog(s) of this gene implicated in cataract and macular degeneration. Orthologous to human GSR (glutathione-disulfide reductase).
SGD Description
Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; cytosolic Glr1p is the main determinant of the glutathione redox state of the mitochondrial intermembrane space; mitochondrial Glr1p has a role in resistance to hyperoxia; also detected in peroxisomes; protein abundance increases in response to DNA replication stress
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR42737:SF2
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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375.6k375.8k376.0k376.2k376.4k376.6k376.8k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions