Enables glutathione-disulfide reductase (NADPH) activity. Involved in several processes, including cell redox homeostasis; glutathione metabolic process; and protein glutathionylation. Located in cytosol; nucleus; and peroxisome. Used to study limb-girdle muscular dystrophy. Human ortholog(s) of this gene implicated in cataract and macular degeneration. Orthologous to human GSR (glutathione-disulfide reductase).
SGD Description
Cytosolic and mitochondrial glutathione oxidoreductase; converts oxidized glutathione to reduced glutathione; cytosolic Glr1p is the main determinant of the glutathione redox state of the mitochondrial intermembrane space; mitochondrial Glr1p has a role in resistance to hyperoxia; also detected in peroxisomes; protein abundance increases in response to DNA replication stress