Gene

DBP1

Species
Saccharomyces cerevisiae
Symbol
DBP1
Name
Dead Box Protein
Synonyms
  • LPH8
  • YPL119C
Biotype
protein coding gene
Automated Description
Enables ATP hydrolysis activity; DNA/RNA helicase activity; and nucleic acid binding activity. Involved in positive regulation of formation of translation preinitiation complex and translational initiation. Located in cytoplasm. Human ortholog(s) of this gene implicated in colorectal cancer and syndromic X-linked intellectual disability. Orthologous to human DDX3X (DEAD-box helicase 3 X-linked) and DDX3Y (DEAD-box helicase 3 Y-linked).
SGD Description
ATP-dependent RNA helicase of the DEAD-box protein family; accelerates eIF4F-dependent assembly of 48S translation preinitiation complex (PIC), stimulating recruitment of mRNAs with long, structured 5'-UTRs; cooperates with DEAD-box RNA helicase and paralog Ded1p, stimulating PIC attachment and highly processive scanning by the 40S ribosomal subunit; binds G-quadruplex (G4) DNA; protein abundance increases in response to DNA replication stress
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR47958:SF32
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
R64-5-1
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324.6k324.8k325.0k325.2k325.4k325.6k325.8k326.0k326.2k

Sequence Details

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Expression

Primary Sources
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions