Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and iron-sulfur cluster binding activity. Involved in several processes, including cardiolipin metabolic process; cellular response to iron ion starvation; and regulation of phosphate transmembrane transport. Located in mitochondrion.
SGD Description
Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; AFT2 has a paralog, AFT1, that arose from the whole genome duplication