Gene

SRP68

Species
Saccharomyces cerevisiae
Symbol
SRP68
Name
Signal Recognition Particle
Synonyms
  • YPL243W
Biotype
protein coding gene
Automated Description
Predicted to enable signal recognition particle binding activity. Involved in SRP-dependent cotranslational protein targeting to membrane. Located in cytoplasm and nuclear periphery. Part of signal recognition particle, endoplasmic reticulum targeting. Human ortholog(s) of this gene implicated in severe congenital neutropenia. Orthologous to human SRP68 (signal recognition particle 68).
SGD Description
Core component of the signal recognition particle (SRP) complex; SRP complex functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12860:SF0
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
Other Sources
None
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
    Disease Qualifier
    Disease
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
      Molecular consequence
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            R64-5-1
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            88.6k88.8k89.0k89.2k89.4k89.6k89.8k90.0k90.2k

            Sequence Details

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            Expression

            Primary Sources
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            SRP68 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              SRP68 role
              SRP68 genetic perturbation
              Interactor gene
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              Interactor role
              Interactor genetic perturbation
              Interaction type
              Phenotype or trait
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